For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.
Job Summary
Due to our continuing growth, we have an exciting opportunity for a talented, highly motivated (associate) scientist at our state-of-the-art drug discovery site in Leiden, the Netherlands.
The (Associate) Scientist will develop and conduct biological assays in accordance with project objectives, supporting project teams. Particularly (primary) human cell–based or stem cell assays in medium and high throughput and across various therapeutic areas. You will be part of a team that is developing and applying models for screening in complex cell-based assays. Technologies that are commonly used at our site are (stem) cell culture, molecular biology, high content imaging, qPCR/ddPCR, immune assays (MSD, ELISA, Luminex etc.), automated liquid handling/robotics and many more. All this is done in a team-oriented, result-driven, international research environment that provides many development opportunities and an excellent career opportunity for an enthusiastic and motivated individual.
Job responsibilities:
- Plan, optimize, validate and execute biological (cell based) assays; experimental design will be done in consultation with the project leader.
- Assess effects of putative therapeutics (compounds, antibodies, siRNA/shRNA, antisense oligonucleotides) and independently analyse and interpret generated data.
- Generate high quality slide decks and confidently present these internally and externally with clear rationale.
- Document performed experiments in (electronic) lab books according to company and patent-acceptable quality standards.
- Consult appropriate scientific literature to plan and troubleshoot studies.
- Maintain strong awareness of the relevant scientific literature and contemporary laboratory practices.
Depending on your experience you will be offered a position as Associate Scientist or Scientist. The job responsibilities and job requirements may differ accordingly.
What do we expect from an (Associate) Scientist:
- MSc with 1-2 years working experience in a relevant discipline.
- Lab experience in cell-based assay development, including molecular biology and compound profiling.
- Able to independently design, plan, execute and analyse own experiments.
- Good oral and written communication skills in English.
- Able to work in a highly dynamic team environment within time- and budget constraints as dictated by the project leader.
Skills and competences that could make a difference:
- Affinity with complex in-vitro biology, such as primary cells, stem cells and/or 3D/organoid cultures.
- Experience in a CRO or Pharma Environment.
- Affinity with robotics and high throughput screening.
- Team-oriented and result-driven attitude
Job Qualifications
What we offer:
In addition, we offer excellent primary and secondary working conditions including:
- Ongoing training and support.
- 26 holidays and the possibility to purchase 5 additional holidays per year.
- Annual one-off 8% holiday pay of your gross annual salary.
- Annual one-off payment based on company results.
- Bicycle (purchase) plan.
- Collective pension with a small own contribution of 2.9%.
- Company fitness plan.
- Flexible Public holidays
- Mobility allowance for the business related travel
About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.
About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.
At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.